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Experienced Carlton midfielder George Hewett's AFL season may be over due to an ongoing back injury, Blues coach Michael Voss says.

Carlton's mounting injury crisis has deepened with experienced midfielder George Hewett in doubt to play again this AFL season.

The Blues, who were firing at 8-2, have slipped to 12-7 and are no certainties to break their nine-year finals drought with a challenging end to the home-and-away season.

After their upset loss to Adelaide last Saturday night, Carlton were rocked by injuries to midfielder Matt Kennedy (jaw), defender Nic Newman (jaw) and forward Corey Durdin (shoulder).

Hewett, who has been outstanding for Carlton after his off-season move from Sydney, has missed the Blues' last two matches.

Carlton coach Michael Voss on Friday revealed the 26-year-old's back injury had not settled and the club was unsure about his return date.

"We're hoping that's not the case (Hewett's season being over) but we've got to wait to see whether the interventions we've put in place have worked," Voss told reporters.

"It's still an assessment because we're still waiting for it to settle down.

"It hasn't quite settled down over the last couple of weeks but we'll get to a point where we need to make some calls on that pretty soon."

Carlton had only regained key players such as ruckman Marc Pittonet and defender Mitch McGovern from long-term injuries before the latest wave of setbacks.

The Blues will head to Brisbane for Sunday's clash with the Lions, who are coming off a heartbreaking second-half fade-out at the MCG against Richmond last Sunday.

Pittonet has been rested for the trip to Queensland, with key defender Caleb Marchbank returning after his latest knee setback.

Paddy Dow, Jack Martin and Jack Newnes are also back.

It will be Voss' first trip to the Gabba as Carlton coach to face the Lions, the club he captained to three premierships and coached for five seasons.

Dashing defender Adam Saad will line up for his 150th career game on the weekend, after playing 61 for Essendon and 48 for Gold Coast.