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US veteran John Isner will face world No.5 Stefanos Tsitsipas in the next round after beating Australia's Rinky Hijikata in straight sets at the Los Cabos Open.

Australia's Rinky Hijikata has been eliminated at the first hurdle of the ATP 250 Tour event in Los Cabos, Mexico.

The 22-year-old world No.110 battled back after a poor opening set but was unable to get the better of American veteran John Isner, going down 6-2 7-6 (7-4) in an hour and 54 minutes on Monday night.

The Sydneysider was broken in the third and seventh games of the opening set and again at the start of the second, but fought back to push his big-serving opponent to a tiebreaker.

The 38-year-old Isner, who fired down 19 aces against Hijikata, will face Greece's world No.5 Stefanos Tsitsipas in the next round.

Fellow Australians Alex de Minaur, the fifth seed, and James Duckworth play their first matches in Los Cobos on Tuesday.

De Minaur will take on Tunisia's Skander Mansouri, while Duckworth faces Otto Virtanen of Finland.